APOB
Gene Ontology Biological Process
- blood coagulation [TAS]
- cholesterol homeostasis [IMP]
- cholesterol metabolic process [IMP]
- cholesterol transport [IMP]
- leukocyte migration [TAS]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle clearance [IMP]
- low-density lipoprotein particle remodeling [IMP]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol storage [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of macrophage derived foam cell differentiation [IDA]
- receptor-mediated endocytosis [TAS]
- response to virus [IEP]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
- very-low-density lipoprotein particle assembly [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- actin cytoskeleton [IDA]
- chylomicron [IDA]
- chylomicron remnant [TAS]
- clathrin-coated endocytic vesicle membrane [TAS]
- cytoplasm [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum lumen [TAS]
- endoplasmic reticulum membrane [TAS]
- endosome lumen [TAS]
- endosome membrane [TAS]
- extracellular region [TAS]
- extracellular space [ISS]
- extracellular vesicular exosome [IDA]
- intermediate-density lipoprotein particle [IDA]
- intracellular membrane-bounded organelle [TAS]
- low-density lipoprotein particle [IDA]
- mature chylomicron [IDA]
- plasma membrane [IDA, TAS]
- very-low-density lipoprotein particle [IDA]
HSP90B1
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- actin rod assembly [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- cellular response to ATP [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- innate immune response [TAS]
- negative regulation of apoptotic process [IMP, TAS]
- protein transport [NAS]
- regulation of phosphoprotein phosphatase activity [IDA]
- response to hypoxia [IDA]
- sequestering of calcium ion [NAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum [IDA, TAS]
- endoplasmic reticulum lumen [IDA, TAS]
- endoplasmic reticulum membrane [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- midbody [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state.
The present study was undertaken to identify and characterize molecular chaperones that assist in the folding of apolipoprotein (apo) B, a secretory protein that requires assembly with lipids (lipidation) for its secretion. Both HepG2 cells, normally secreting full-length apoB (apoB-100), and C127 cells transfected to secrete truncated forms of apoB, apoB-41, apoB-29, and apoB-17, respectively, were employed. C127 cells were ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APOB HSP90B1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| APOB HSP90B1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID