HAP1
Gene Ontology Biological Process
- anterograde axon cargo transport [ISS]
- brain development [NAS]
- negative regulation of beta-amyloid formation [ISS]
- neurotrophin TRK receptor signaling pathway [ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [ISS]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISS]
- positive regulation of neurotrophin production [ISS]
- positive regulation of nonmotile primary cilium assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- protein localization [IMP]
- regulation of exocytosis [ISS]
- regulation of organelle transport along microtubule [ISS]
- retrograde axon cargo transport [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PCM1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- centrosome organization [IMP]
- cilium assembly [IMP]
- cytoplasmic microtubule organization [IMP]
- interkinetic nuclear migration [ISS]
- intraciliary transport involved in cilium morphogenesis [IMP]
- microtubule anchoring [ISS]
- mitotic cell cycle [TAS]
- negative regulation of neurogenesis [ISS]
- positive regulation of intracellular protein transport [IMP]
- protein localization to centrosome [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the HD protein huntingtin. Huntingtin's localization within the cell includes an association with cytoskeletal elements and vesicles. We previously identified a protein (HAP1) which binds to huntingtin in a glutamine repeat length-dependent manner. We now report that HAP1 interacts with cytoskeletal proteins, namely the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HAP1 PCM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9922 | BioGRID | 3283522 |
Curated By
- BioGRID