CSNK1E
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
CRY1
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [ISS]
- blue light signaling pathway [NAS]
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- gluconeogenesis [ISS]
- glucose homeostasis [ISS]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of protein ubiquitination [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- regulation of DNA damage checkpoint [ISS]
- regulation of circadian rhythm [ISS]
- response to glucagon [ISS]
Gene Ontology Molecular Function- DNA (6-4) photolyase activity [IDA]
- DNA binding [TAS]
- blue light photoreceptor activity [NAS]
- core promoter binding [ISS]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- double-stranded DNA binding [IDA]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [IPI]
- protein binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin binding [ISS]
- DNA (6-4) photolyase activity [IDA]
- DNA binding [TAS]
- blue light photoreceptor activity [NAS]
- core promoter binding [ISS]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- double-stranded DNA binding [IDA]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [IPI]
- protein binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin binding [ISS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.999998414 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999998414, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- BioPlex HCT HCT116 cells CompPASS score = 1, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CSNK1E CRY1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3352577 | |
| CSNK1E CRY1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1443981 | |
| CSNK1E CRY1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2219494 | |
| CSNK1E CRY1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 941242 | |
| CRY1 CSNK1E | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID