BAIT
PRKCE
5830406C15Rik, PKC[e], PKCepsilon, Pkce, R75156
protein kinase C, epsilon
GO Process (36)
GO Function (13)
GO Component (13)
Gene Ontology Biological Process
- TRAM-dependent toll-like receptor 4 signaling pathway [IMP]
- cellular response to ethanol [IGI]
- cellular response to hypoxia [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- chemosensory behavior [TAS]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [IMP]
- locomotory exploration behavior [IGI]
- macrophage activation involved in immune response [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of mitochondrial calcium ion concentration [ISO]
- negative regulation of mitochondrial membrane potential [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [ISO]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IDA, IMP]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell-substrate adhesion [IGI, IMP]
- positive regulation of cellular glucuronidation [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of fibroblast migration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of lipid catabolic process [IMP]
- positive regulation of mucus secretion [IMP]
- positive regulation of receptor activity [IDA]
- positive regulation of synaptic transmission, GABAergic [IMP]
- positive regulation of wound healing [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- regulation of lipid metabolic process [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of release of sequestered calcium ion into cytosol [IDA]
- release of sequestered calcium ion into cytosol [IMP]
- response to morphine [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- SH3 domain binding [ISO]
- actin monomer binding [IDA]
- calcium-independent protein kinase C activity [IDA]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [IDA]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- receptor activator activity [IDA]
- receptor binding [ISO]
- 14-3-3 protein binding [IPI]
- SH3 domain binding [ISO]
- actin monomer binding [IDA]
- calcium-independent protein kinase C activity [IDA]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [IDA]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- receptor activator activity [IDA]
- receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
SRC
AW259666, pp60c-src, RP23-169M4.1
Rous sarcoma oncogene
GO Process (29)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- bone resorption [IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- cell migration [IMP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- epidermal growth factor receptor signaling pathway [IBA]
- forebrain development [IGI]
- innate immune response [IBA]
- intracellular signal transduction [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [IBA]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- oogenesis [IMP]
- osteoclast development [IGI]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of podosome assembly [IDA, IGI]
- progesterone receptor signaling pathway [IBA]
- protein phosphorylation [IDA]
- regulation of cell cycle [IBA]
- regulation of cell projection assembly [IGI]
- regulation of cell proliferation [IBA]
- regulation of intracellular estrogen receptor signaling pathway [IMP]
- regulation of protein binding [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- uterus development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase.
Our laboratory has conducted multiple functional proteomic analyses to characterize the components of protein kinase C (PKC)epsilon cardioprotective signaling complexes and found that activation of PKCepsilon induces dynamic modulation of these complexes. In addition, it is known that signal transduction within a complex involves the formation of modules, one of which has been shown to include PKCepsilon and Src tyrosine ... [more]
Am. J. Physiol. Heart Circ. Physiol. Mar. 01, 2002; 282(3);H1166-71 [Pubmed: 11834516]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID