SCNN1G
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TSG101
Gene Ontology Biological Process
- cell cycle arrest [ISO]
- cell differentiation [ISO]
- endosome to lysosome transport [IMP]
- keratinocyte differentiation [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of exosomal secretion [ISO]
- protein monoubiquitination [IDA]
- regulation of cell growth [ISO]
- regulation of extracellular vesicular exosome assembly [ISO]
- regulation of nucleic acid-templated transcription [IDA]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO, ISS]
- viral budding [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of new partners of the epithelial sodium channel alpha subunit.
A fine regulation of the amiloride-sensitive Epithelial Sodium Channel (ENaC), made of alpha, beta and gamma subunits, is crucial for maintenance of Na+ balance and blood pressure. Both beta- and gamma-ENaC participate in negative regulation by interacting with Nedd4-2, an E3 ubiquitin-ligase. Disruption of this interaction results in increased ENaC activity (Liddle syndrome). By two-hybrid screenings, we identified new potential ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID