BAIT
NDE1
2810027M15Rik, AU042936, AW822251, Nude, mNudE
nuclear distribution gene E homolog 1 (A nidulans)
GO Process (13)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- centrosome duplication [IMP]
- centrosome localization [IBA]
- cerebral cortex development [IGI, ISO]
- chromosome segregation [IBA]
- establishment of chromosome localization [IBA, ISO]
- establishment of mitotic spindle orientation [IBA, ISO]
- forebrain development [IMP]
- microtubule nucleation [IDA]
- microtubule organizing center organization [IMP]
- mitotic centrosome separation [IBA]
- neuroblast proliferation [IMP]
- neuron migration [IMP]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PAFAH1B1
LIS-1, Lis1, MMS10-U, Mdsh, Ms10u, Pafaha, RP23-194P5.2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
GO Process (35)
GO Function (7)
GO Component (22)
Gene Ontology Biological Process
- acrosome assembly [IMP]
- actin cytoskeleton organization [IMP]
- adult locomotory behavior [IMP, ISO]
- ameboidal-type cell migration [IMP]
- brain morphogenesis [ISO]
- cell migration [IMP]
- cerebral cortex development [IGI, IMP, ISO]
- cerebral cortex neuron differentiation [ISO]
- corpus callosum morphogenesis [ISO]
- establishment of centrosome localization [ISO]
- establishment of mitotic spindle orientation [ISO]
- hippocampus development [IGI, IMP]
- layer formation in cerebral cortex [IGI]
- learning or memory [IMP]
- microtubule cytoskeleton organization [IGI, IMP]
- microtubule organizing center organization [ISO]
- microtubule-based process [ISO]
- negative regulation of JNK cascade [IGI]
- negative regulation of neuron projection development [ISO]
- neuroblast proliferation [IMP]
- neuromuscular process controlling balance [IMP, ISO]
- neuron migration [IGI, IMP, ISO]
- nuclear envelope disassembly [IMP]
- nuclear migration [ISO]
- osteoclast development [IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of mitotic cell cycle [ISO]
- protein secretion [IMP]
- regulation of Rho GTPase activity [IMP]
- retrograde axon cargo transport [IDA]
- stem cell division [ISO]
- synaptic transmission [IMP]
- transmission of nerve impulse [IMP]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- astral microtubule [ISO]
- axon [ISO]
- cell [IGI]
- cell cortex [ISO]
- cell leading edge [IDA]
- centrosome [IDA, ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- intracellular [IGI]
- kinesin complex [ISO]
- kinetochore [ISO]
- microtubule associated complex [IDA, ISO]
- microtubule cytoskeleton [IDA]
- motile primary cilium [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nonmotile primary cilium [IDA]
- nuclear envelope [ISO, ISS]
- perinuclear region of cytoplasm [IDA]
- vesicle [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.
LIS1, a microtubule-associated protein, is required for neuronal migration, but the precise mechanism of LIS1 function is unknown. We identified a LIS1 interacting protein encoded by a mouse homolog of NUDE, a nuclear distribution gene in A. nidulans and a multicopy suppressor of the LIS1 homolog, NUDF. mNudE is located in the centrosome or microtubule organizing center (MTOC), and interacts ... [more]
Neuron Dec. 01, 2000; 28(3);665-79 [Pubmed: 11163258]
Throughput
- Low Throughput
Curated By
- BioGRID