NDE1
Gene Ontology Biological Process
- centrosome duplication [IMP]
- centrosome localization [IBA]
- cerebral cortex development [IGI, ISO]
- chromosome segregation [IBA]
- establishment of chromosome localization [IBA, ISO]
- establishment of mitotic spindle orientation [IBA, ISO]
- forebrain development [IMP]
- microtubule nucleation [IDA]
- microtubule organizing center organization [IMP]
- mitotic centrosome separation [IBA]
- neuroblast proliferation [IMP]
- neuron migration [IMP]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PAFAH1B1
Gene Ontology Biological Process
- acrosome assembly [IMP]
- actin cytoskeleton organization [IMP]
- adult locomotory behavior [IMP, ISO]
- ameboidal-type cell migration [IMP]
- brain morphogenesis [ISO]
- cell migration [IMP]
- cerebral cortex development [IGI, IMP, ISO]
- cerebral cortex neuron differentiation [ISO]
- corpus callosum morphogenesis [ISO]
- establishment of centrosome localization [ISO]
- establishment of mitotic spindle orientation [ISO]
- hippocampus development [IGI, IMP]
- layer formation in cerebral cortex [IGI]
- learning or memory [IMP]
- microtubule cytoskeleton organization [IGI, IMP]
- microtubule organizing center organization [ISO]
- microtubule-based process [ISO]
- negative regulation of JNK cascade [IGI]
- negative regulation of neuron projection development [ISO]
- neuroblast proliferation [IMP]
- neuromuscular process controlling balance [IMP, ISO]
- neuron migration [IGI, IMP, ISO]
- nuclear envelope disassembly [IMP]
- nuclear migration [ISO]
- osteoclast development [IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of mitotic cell cycle [ISO]
- protein secretion [IMP]
- regulation of Rho GTPase activity [IMP]
- retrograde axon cargo transport [IDA]
- stem cell division [ISO]
- synaptic transmission [IMP]
- transmission of nerve impulse [IMP]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- astral microtubule [ISO]
- axon [ISO]
- cell [IGI]
- cell cortex [ISO]
- cell leading edge [IDA]
- centrosome [IDA, ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- intracellular [IGI]
- kinesin complex [ISO]
- kinetochore [ISO]
- microtubule associated complex [IDA, ISO]
- microtubule cytoskeleton [IDA]
- motile primary cilium [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nonmotile primary cilium [IDA]
- nuclear envelope [ISO, ISS]
- perinuclear region of cytoplasm [IDA]
- vesicle [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.
LIS1, a microtubule-associated protein, is required for neuronal migration, but the precise mechanism of LIS1 function is unknown. We identified a LIS1 interacting protein encoded by a mouse homolog of NUDE, a nuclear distribution gene in A. nidulans and a multicopy suppressor of the LIS1 homolog, NUDF. mNudE is located in the centrosome or microtubule organizing center (MTOC), and interacts ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID