BAIT
LHCGR
HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5
luteinizing hormone/choriogonadotropin receptor
GO Process (10)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- activation of adenylate cyclase activity [ISS]
- cellular response to gonadotropin stimulus [ISS]
- cognition [IMP]
- male genitalia development [TAS]
- male gonad development [TAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of cAMP-mediated signaling [ISS]
- positive regulation of inositol trisphosphate biosynthetic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARRB2
ARB2, ARR2, BARR2
arrestin, beta 2
GO Process (18)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA, IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of natural killer cell mediated cytotoxicity [IMP]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of protein ubiquitination [IGI]
- positive regulation of receptor internalization [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- receptor internalization [IDA]
- regulation of androgen receptor signaling pathway [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.
Arrestin2 binding to the active but unphosphorylated luteinizing hormone/choriogonadotropin receptor (LH/CG R) in ovarian follicles is triggered by activation of ADP-ribosylation factor 6 (ARF6) and leads to uncoupling of this receptor from cAMP signaling. We sought to determine how arrestin2 binds to LH/CG R, if binding is of high affinity, and if the receptor also binds arrestin3. Desensitization of intact ... [more]
J. Biol. Chem. May. 17, 2002; 277(20);17916-27 [Pubmed: 11867621]
Throughput
- Low Throughput
Curated By
- BioGRID