Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate.

Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M

Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neuro degrees enerative disorder associated with CAG/glutamine repeat expansion. While the DRPLA gene is ubiquitously expressed, neuron death occurs in specific anatomical areas of the brain. This predicts that the DRPLA protein interacts with other proteins and that these interactions may play a role in pathogenesis. Here, we describe a protein that binds ... [more]

Hum. Mol. Genet. Jun. 01, 1999; 8(6);947-57 [Pubmed: 10332026]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

ATN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein domain specific binding [IPI]transcription corepressor activity [IDA]

Gene Ontology Cellular Component

CTNND2