BAIT
ATN1
B37, D12S755E, DRPLA, HRS, NOD
atrophin 1
GO Process (3)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DVL1
DVL, DVL1L1, DVL1P1, RP5-890O3.5
dishevelled segment polarity protein 1
GO Process (18)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- canonical Wnt signaling pathway [IDA]
- dendrite morphogenesis [ISS]
- heart development [NAS]
- negative regulation of protein binding [IDA]
- negative regulation of protein kinase activity [IDA]
- neural tube development [IEP]
- neuromuscular junction development [ISS]
- neurotransmitter secretion [ISS]
- planar cell polarity pathway involved in neural tube closure [IBA]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IMP]
- receptor clustering [ISS]
- regulation of neurotransmitter levels [ISS]
- synapse organization [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate.
Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neuro degrees enerative disorder associated with CAG/glutamine repeat expansion. While the DRPLA gene is ubiquitously expressed, neuron death occurs in specific anatomical areas of the brain. This predicts that the DRPLA protein interacts with other proteins and that these interactions may play a role in pathogenesis. Here, we describe a protein that binds ... [more]
Hum. Mol. Genet. Jun. 01, 1999; 8(6);947-57 [Pubmed: 10332026]
Throughput
- Low Throughput
Curated By
- BioGRID