BAIT

THRB

C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
thyroid hormone receptor, beta
Homo sapiens
PREY

COPS2

ALIEN, CSN2, SGN2, TRIP15
COP9 signalosome subunit 2
UPS Project
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.

Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A

Some members of nuclear hormone receptors, such as the thyroid hormone receptor (TR), silence gene expression in the absence of the hormone. Corepressors, which bind to the receptor's silencing domain, are involved in this repression. Hormone binding leads to dissociation of corepressors and binding of coactivators, which in turn mediate gene activation. Here, we describe the characteristics of Alien, a ... [more]

Mol. Cell. Biol. May. 01, 1999; 19(5);3383-94 [Pubmed: 10207062]

Throughput

  • Low Throughput

Curated By

  • BioGRID