FLT4
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cellular response to vascular endothelial growth factor stimulus [IDA, IMP]
- lymph vessel development [ISS]
- lymphangiogenesis [IMP, ISS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- protein autophosphorylation [IDA]
- regulation of blood vessel remodeling [ISS]
- sprouting angiogenesis [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IGI, IMP, TAS]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHC1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [IDA]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IBA, ISS, TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [TAS]
- platelet activation [TAS]
- positive regulation of DNA replication [ISS]
- positive regulation of cell proliferation [NAS]
- regulation of epidermal growth factor-activated receptor activity [TAS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase.
The FLT4 gene encodes two isoforms of a tyrosine kinase receptor, which belongs to the family of receptors for vascular endothelial growth factor. As the result of an alternative processing of primary mRNA transcripts, the long isoform differs from the short isoform by an additional stretch of 65 amino acid residues located at the C terminus and containing three tyrosine ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHC1 FLT4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FLT4 SHC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FLT4 SHC1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| FLT4 SHC1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID