CAV3
Gene Ontology Biological Process
- T-tubule organization [TAS]
- caveola assembly [IDA]
- cell differentiation [ISS]
- cell growth [ISS]
- cholesterol homeostasis [ISS]
- endocytosis [ISS]
- glucose homeostasis [ISS]
- membrane raft organization [ISS]
- muscle cell cellular homeostasis [ISS]
- muscle organ development [TAS]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [ISS]
- negative regulation of calcium ion transport [IDA]
- negative regulation of cardiac muscle hypertrophy [IMP]
- negative regulation of cell size [IMP]
- negative regulation of nitric-oxide synthase activity [ISS]
- negative regulation of potassium ion transmembrane transport [ISS]
- negative regulation of potassium ion transmembrane transporter activity [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of protein localization to cell surface [NAS]
- negative regulation of sarcomere organization [IMP]
- plasma membrane organization [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of microtubule polymerization [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [NAS]
- protein localization [ISS]
- protein localization to plasma membrane [ISS]
- regulation of calcium ion import [IDA]
- regulation of calcium ion transmembrane transporter activity [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of heart contraction [ISS]
- regulation of heart rate [IMP]
- regulation of membrane depolarization during cardiac muscle cell action potential [IMP]
- regulation of membrane potential [IDA]
- regulation of nerve growth factor receptor activity [IMP]
- regulation of signal transduction by receptor internalization [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane depolarization [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- triglyceride metabolic process [ISS]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNX3
Gene Ontology Biological Process
- intralumenal vesicle formation [IMP]
- membrane invagination [IDA]
- negative regulation of early endosome to late endosome transport [IDA]
- negative regulation of phagocytosis [IMP]
- negative regulation of protein catabolic process [IDA]
- negative regulation of protein transport [IDA]
- negative regulation of viral entry into host cell [IDA]
- positive regulation of neuron projection development [ISS]
- protein to membrane docking [IDA]
- regulation of Wnt signaling pathway [IMP]
- response to bacterium [IDA]
- vesicle organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.938886394 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.938886394, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CAV3 SNX3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9956 | BioGRID | 2237433 |
Curated By
- BioGRID