BAIT
GRB2
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
growth factor receptor-bound protein 2
GO Process (20)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Ras protein signal transduction [TAS]
- T cell costimulation [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- cellular response to ionizing radiation [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IPI, TAS]
- leukocyte migration [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- receptor internalization [IMP]
- signal transduction in response to DNA damage [IMP]
Gene Ontology Molecular Function- SH3 domain binding [IDA]
- SH3/SH2 adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [IPI]
- identical protein binding [IPI]
- insulin receptor substrate binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- SH3 domain binding [IDA]
- SH3/SH2 adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [IPI]
- identical protein binding [IPI]
- insulin receptor substrate binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
HCLS1
CTTNL, HS1, lckBP1, p75
hematopoietic cell-specific Lyn substrate 1
GO Process (17)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- cellular response to cytokine stimulus [IMP]
- erythrocyte differentiation [ISS]
- intracellular signal transduction [TAS]
- negative regulation of leukocyte apoptotic process [IMP]
- positive regulation of actin cytoskeleton reorganization [IC]
- positive regulation of cell proliferation [ISS]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of tyrosine phosphorylation of STAT protein [ISS]
- regulation of actin filament polymerization [IMP]
- regulation of transcription, DNA-templated [TAS]
- response to hormone [ISS]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.
To analyze the growth factor receptor-bound protein 2 (Grb2) signaling pathway in lymphoid cells, we used expression cloning to isolate the genes encoding proteins that associate with Grb2. We find that the Src homology 3 domains of Grb2 directly associate, in vitro and in vivo, with murine hemopoietic specific protein 1 (HS1), a protein identical to Lck-binding protein 1. Because ... [more]
J. Immunol. Jul. 15, 1998; 161(2);625-30 [Pubmed: 9670936]
Throughput
- Low Throughput
Curated By
- BioGRID