BAIT
AVPR2
ADHR, DI1, DIR, DIR3, NDI, V2R
arginine vasopressin receptor 2
GO Process (12)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- cellular response to hormone stimulus [IBA]
- excretion [TAS]
- hemostasis [TAS]
- positive regulation of gene expression [ISS]
- positive regulation of protein ubiquitination [NAS]
- positive regulation of vasoconstriction [IBA]
- regulation of systemic arterial blood pressure by vasopressin [IBA]
- response to peptide [IBA]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FITM2
C20orf142, Fit2, dJ881L22.2
fat storage-inducing transmembrane protein 2
GO Process (8)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- cellular triglyceride homeostasis [ISS]
- cytoskeleton organization [IMP]
- lipid particle organization [IBA, ISS]
- lipid storage [IBA]
- phospholipid biosynthetic process [IBA]
- positive regulation of sequestering of triglyceride [ISS]
- regulation of cell morphogenesis [IMP]
- regulation of triglyceride biosynthetic process [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.830060224 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.830060224, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID