LRRC4C
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SULF1
Gene Ontology Biological Process
- bone development [ISS]
- cartilage development [ISS]
- chondrocyte development [ISS]
- embryonic skeletal system development [ISS]
- esophagus smooth muscle contraction [ISS]
- glial cell-derived neurotrophic factor receptor signaling pathway [ISS]
- glomerular basement membrane development [ISS]
- glomerular filtration [ISS]
- heparan sulfate proteoglycan metabolic process [IDA, NAS]
- innervation [ISS]
- kidney development [ISS]
- negative regulation of angiogenesis [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP, ISS]
- negative regulation of prostatic bud formation [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- vascular endothelial growth factor receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.996923729 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.996923729, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
LRRC4C SULF1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9992 | BioGRID | 2231557 |
Curated By
- BioGRID