BAIT
ATP2B2
PMCA2, PMCA2a, PMCA2i
ATPase, Ca++ transporting, plasma membrane 2
GO Process (9)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DLG4
Dlgh4, PSD95, Sap90
discs, large homolog 4 (Drosophila)
GO Process (19)
GO Function (14)
GO Component (24)
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- dendritic spine morphogenesis [IMP, ISO]
- establishment of protein localization [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- negative regulation of receptor internalization [IDA]
- neuromuscular process controlling balance [ISO, ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of synaptic transmission [IDA]
- protein complex assembly [ISO, ISS]
- protein localization to synapse [IMP, ISO]
- receptor localization to synapse [IMP]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA]
- regulation of grooming behavior [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- social behavior [ISO, ISS]
- synaptic vesicle maturation [ISO, ISS]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO, ISS]
- cell junction [ISO, ISS]
- cerebellar mossy fiber [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO, ISS]
- dendrite [ISO]
- dendrite cytoplasm [IDA]
- dendritic spine [ISS]
- endoplasmic reticulum [ISO, ISS]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO, ISS]
- ionotropic glutamate receptor complex [ISO, ISS]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [ISO, ISS]
- neuron spine [ISO, ISS]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [ISO]
- synaptic vesicle [ISO, ISS]
- voltage-gated potassium channel complex [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.
Spatial and temporal regulation of intracellular Ca(2+) signaling depends on localized Ca(2+) microdomains containing the requisite molecular components for Ca(2+) influx, efflux, and signal transmission. Plasma membrane Ca(2+)-ATPase (PMCA) isoforms of the "b" splice type contain predicted PDZ (PSD95/Dlg/ZO-1) interaction domains. The COOH-terminal tail of PMCA2b isolated the membrane-associated guanylate kinase (MAGUK) protein SAP97/hDlg as a binding partner in a ... [more]
J. Biol. Chem. Jun. 15, 2001; 276(24);21594-600 [Pubmed: 11274188]
Throughput
- Low Throughput
Curated By
- BioGRID