ATP2B4
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion homeostasis [IC]
- calcium ion import across plasma membrane [IC]
- calcium ion transmembrane transport [IMP]
- cellular calcium ion homeostasis [IDA]
- cellular response to epinephrine stimulus [IDA]
- ion transmembrane transport [TAS]
- negative regulation of adrenergic receptor signaling pathway involved in heart process [IDA]
- negative regulation of arginine catabolic process [IDA]
- negative regulation of calcineurin-NFAT signaling cascade [IDA]
- negative regulation of cardiac muscle hypertrophy in response to stress [IMP]
- negative regulation of citrulline biosynthetic process [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- negative regulation of nitric oxide mediated signal transduction [IDA]
- negative regulation of nitric-oxide synthase activity [IDA]
- negative regulation of peptidyl-cysteine S-nitrosylation [NAS]
- negative regulation of the force of heart contraction [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of sodium ion transmembrane transport [IC]
- regulation of transcription from RNA polymerase II promoter [IMP]
- response to hydrostatic pressure [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLG1
Gene Ontology Biological Process
- T cell activation [ISO]
- T cell cytokine production [ISO]
- actin filament organization [ISO, ISS]
- activation of protein kinase activity [ISO]
- amyloid precursor protein metabolic process [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- cell adhesion [IEP]
- cortical actin cytoskeleton organization [ISO, ISS]
- embryonic skeletal system morphogenesis [ISO]
- endothelial cell proliferation [ISO, ISS]
- hard palate development [ISO]
- immunological synapse formation [ISO]
- lens development in camera-type eye [ISO]
- membrane raft organization [ISO]
- negative regulation of T cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of mitotic cell cycle [ISO, ISS]
- negative regulation of protein kinase B signaling [ISO]
- peristalsis [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of potassium ion transport [IMP, ISO]
- protein localization [ISO]
- protein localization to plasma membrane [ISO]
- regulation of membrane potential [ISO]
- regulation of myelination [ISO]
- regulation of protein localization [IMP]
- reproductive structure development [ISO]
- single organismal cell-cell adhesion [ISO, ISS]
- smooth muscle tissue development [ISO]
- tight junction assembly [ISO]
- tissue morphogenesis [ISO]
- ureteric bud development [ISO]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [IPI]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO, ISS]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein kinase binding [IPI, ISO, ISS]
- L27 domain binding [ISO]
- PDZ domain binding [IPI]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO, ISS]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein kinase binding [IPI, ISO, ISS]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [IDA]
- basal lamina [ISO]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA, ISO, ISS]
- cell junction [ISO]
- cell projection membrane [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [ISO]
- lateral loop [ISO]
- lateral plasma membrane [ISO]
- membrane raft [ISO]
- microtubule [ISO]
- myelin sheath abaxonal region [ISO]
- neuromuscular junction [ISO]
- neuron projection [IDA]
- node of Ranvier [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO, TAS]
- postsynaptic membrane [TAS]
- presynaptic membrane [IDA]
- synapse [ISO]
- tight junction [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.
Spatial and temporal regulation of intracellular Ca(2+) signaling depends on localized Ca(2+) microdomains containing the requisite molecular components for Ca(2+) influx, efflux, and signal transmission. Plasma membrane Ca(2+)-ATPase (PMCA) isoforms of the "b" splice type contain predicted PDZ (PSD95/Dlg/ZO-1) interaction domains. The COOH-terminal tail of PMCA2b isolated the membrane-associated guanylate kinase (MAGUK) protein SAP97/hDlg as a binding partner in a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID