ATP2B4
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion homeostasis [IC]
- calcium ion import across plasma membrane [IC]
- calcium ion transmembrane transport [IMP]
- cellular calcium ion homeostasis [IDA]
- cellular response to epinephrine stimulus [IDA]
- ion transmembrane transport [TAS]
- negative regulation of adrenergic receptor signaling pathway involved in heart process [IDA]
- negative regulation of arginine catabolic process [IDA]
- negative regulation of calcineurin-NFAT signaling cascade [IDA]
- negative regulation of cardiac muscle hypertrophy in response to stress [IMP]
- negative regulation of citrulline biosynthetic process [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- negative regulation of nitric oxide mediated signal transduction [IDA]
- negative regulation of nitric-oxide synthase activity [IDA]
- negative regulation of peptidyl-cysteine S-nitrosylation [NAS]
- negative regulation of the force of heart contraction [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of sodium ion transmembrane transport [IC]
- regulation of transcription from RNA polymerase II promoter [IMP]
- response to hydrostatic pressure [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLG3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.
Spatial and temporal regulation of intracellular Ca(2+) signaling depends on localized Ca(2+) microdomains containing the requisite molecular components for Ca(2+) influx, efflux, and signal transmission. Plasma membrane Ca(2+)-ATPase (PMCA) isoforms of the "b" splice type contain predicted PDZ (PSD95/Dlg/ZO-1) interaction domains. The COOH-terminal tail of PMCA2b isolated the membrane-associated guanylate kinase (MAGUK) protein SAP97/hDlg as a binding partner in a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID