CPB2
Gene Ontology Cellular Component
C5
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- cell chemotaxis [TAS]
- cell surface receptor signaling pathway [TAS]
- chemotaxis [TAS]
- complement activation [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- negative regulation of macrophage chemotaxis [IDA]
- positive regulation of chemokine secretion [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- response to stress [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N.
Pro-carboxypeptidase R (proCPR), also known as thrombin-activatable fibrinolysis inhibitor (TAFI), precursor of carboxypeptidase U and plasma carboxypeptidase B is present in plasma and following activation by thrombin/thrombomodulin and/or plasmin can remove arginine from the carboxyterminal of C3a and C5a. We have shown that this enzyme can remove terminal arginine from the C5a octapeptide much more efficiently than the classical anaphylatoxin ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID