BAIT
GMEB1
P96PIF, PIF96
glucocorticoid modulatory element binding protein 1
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [TAS]
Homo sapiens
PREY
UBE2I
UbcE2A
ubiquitin-conjugating enzyme E2I
GO Process (10)
GO Function (12)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein sumoylation [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of receptor activity [IDA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function- HLH domain binding [ISO]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IDA, ISO]
- bHLH transcription factor binding [IPI]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase activity [IBA]
- ubiquitin protein ligase binding [IBA]
- ubiquitin-protein transferase activity [IDA]
- HLH domain binding [ISO]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IDA, ISO]
- bHLH transcription factor binding [IPI]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase activity [IBA]
- ubiquitin protein ligase binding [IBA]
- ubiquitin-protein transferase activity [IDA]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors.
The EC(50) of agonists and the partial agonist activity of antagonists are crucial parameters for steroid hormone control of gene expression and endocrine therapies. These parameters have been shown to be modulated by a naturally occurring cis-acting element, called the glucocorticoid modulatory element (GME) that binds two proteins, GMEB-1 and -2. We now present evidence that the GMEBs contact Ubc9, ... [more]
J. Biol. Chem. Apr. 12, 2002; 277(15);12541-9 [Pubmed: 11812797]
Throughput
- Low Throughput
Curated By
- BioGRID