CHRNB2
Gene Ontology Biological Process
- B cell activation [ISS]
- associative learning [ISS]
- behavioral response to nicotine [IMP]
- calcium ion transport [ISS]
- cation transmembrane transport [IDA, TAS]
- central nervous system projection neuron axonogenesis [ISS]
- cognition [IMP]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- lateral geniculate nucleus development [ISS]
- learning [IMP]
- locomotory behavior [ISS]
- membrane depolarization [ISS]
- memory [IMP]
- negative regulation of action potential [ISS]
- neurological system process [IMP]
- optic nerve morphogenesis [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of dopamine secretion [ISS]
- regulation of circadian sleep/wake cycle, REM sleep [ISS]
- regulation of dendrite morphogenesis [ISS]
- regulation of dopamine metabolic process [ISS]
- regulation of dopamine secretion [ISS]
- regulation of synapse assembly [ISS]
- regulation of synaptic transmission, dopaminergic [ISS]
- response to cocaine [ISS]
- response to ethanol [ISS]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- sensory perception of pain [ISS]
- sensory perception of sound [ISS]
- signal transduction [IDA]
- smooth muscle contraction [ISS]
- social behavior [ISS]
- synaptic transmission [TAS]
- synaptic transmission involved in micturition [ISS]
- synaptic transmission, cholinergic [ISS]
- vestibulocochlear nerve development [ISS]
- visual learning [IMP]
- visual perception [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRNA3
Gene Ontology Biological Process
- activation of transmembrane receptor protein tyrosine kinase activity [ISS]
- behavioral response to nicotine [IMP]
- cation transmembrane transport [IDA, TAS]
- cation transport [IDA, TAS]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- locomotory behavior [ISS]
- nervous system development [IMP]
- regulation of acetylcholine secretion, neurotransmission [ISS]
- regulation of dendrite morphogenesis [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of membrane potential [ISS]
- regulation of smooth muscle contraction [ISS]
- signal transduction [IDA]
- synaptic transmission [TAS]
- synaptic transmission involved in micturition [IMP]
- synaptic transmission, cholinergic [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.99376144 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.99376144, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNB2 CHRNA3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CHRNA3 CHRNB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID