RAP1A
Gene Ontology Biological Process
- Rap protein signal transduction [IMP]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- cellular response to cAMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- energy reserve metabolic process [TAS]
- establishment of endothelial barrier [IMP]
- nerve growth factor signaling pathway [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of Rap GTPase activity [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of vasculogenesis [ISS]
- protein transport [IDA]
- regulation of cell junction assembly [IMP]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAPGEF2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [NAS]
- Rap protein signal transduction [IMP]
- adenylate cyclase-activating adrenergic receptor signaling pathway [IDA]
- blood vessel development [ISS]
- brain-derived neurotrophic factor receptor signaling pathway [ISS]
- cAMP-mediated signaling [IDA, NAS]
- cellular response to cAMP [IDA]
- cellular response to cGMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- establishment of endothelial barrier [IMP]
- forebrain neuron development [ISS]
- intracellular signal transduction [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of dendrite morphogenesis [IDA]
- negative regulation of melanin biosynthetic process [ISS]
- nerve growth factor signaling pathway [ISS]
- neuron migration [ISS]
- neuron projection development [IDA]
- neuropeptide signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of Rap GTPase activity [IDA, IMP]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of dendritic cell apoptotic process [IDA]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of vasculogenesis [ISS]
- regulation of cell junction assembly [IMP]
- regulation of synaptic plasticity [ISS]
- small GTPase mediated signal transduction [TAS]
- ventricular system development [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.
Although the Ras subfamily of GTPases consists of approximately 20 members, only a limited number of guanine nucleotide exchange factors (GEFs) that couple extracellular stimuli to Ras protein activation have been identified. Furthermore, no novel downstream effectors have been identified for the M-Ras/R-Ras3 GTPase. Here we report the identification and characterization of three Ras family GEFs that are most abundantly ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAPGEF2 RAP1A | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 304394 |
Curated By
- BioGRID