BAIT
RALA
RAL
v-ral simian leukemia viral oncogene homolog A (ras related)
GO Process (10)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- actin cytoskeleton reorganization [IDA]
- chemotaxis [TAS]
- cytokinesis [IDA]
- membrane organization [TAS]
- membrane raft localization [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of filopodium assembly [IDA]
- regulation of exocytosis [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EXOC4
ALR, Sec8, Sec8l1
exocyst complex component 4
GO Process (9)
GO Function (4)
GO Component (15)
Gene Ontology Biological Process
- Golgi to transport vesicle transport [IDA]
- establishment of cell polarity [IMP]
- membrane biogenesis [IMP]
- oligodendrocyte differentiation [IMP]
- positive regulation of calcium-mediated signaling [IMP]
- protein targeting to membrane [IMP]
- regulation of protein transport [IMP]
- synaptic transmission [IMP]
- vesicle targeting [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cytoplasm [ISO]
- dendritic shaft [IDA]
- endosome [IDA]
- exocyst [TAS]
- growth cone [IDA]
- growth cone membrane [ISO]
- membrane [ISO]
- myelin sheath [IDA]
- myelin sheath abaxonal region [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- postsynaptic density [IDA]
- protein complex [IDA]
- synapse [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.
Ral is a small GTPase involved in critical cellular signaling pathways. The two isoforms, RalA and RalB, are widely distributed in different tissues, with RalA being enriched in brain. The best characterized RalA signaling pathways involve RalBP1 and phospholipase D. To investigate RalA signaling in neuronal cells we searched for RalA-binding proteins in brain. We found at least eight proteins ... [more]
J. Biol. Chem. Aug. 10, 2001; 276(32);29792-7 [Pubmed: 11406615]
Throughput
- Low Throughput
Curated By
- BioGRID