MYLK
Gene Ontology Biological Process
- actin filament organization [IBA]
- aorta smooth muscle tissue morphogenesis [IMP]
- bleb assembly [IMP]
- cellular hypotonic response [IDA]
- muscle contraction [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of wound healing [IDA]
- smooth muscle contraction [IBA, ISS]
- tonic smooth muscle contraction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MLC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basolateral plasma membrane [IDA]
- caveola [ISS]
- clathrin-coated vesicle [ISS]
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- early endosome [ISS]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- integral component of membrane [IDA]
- lysosome [ISS]
- membrane raft [ISS]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- recycling endosome [ISS]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Inhibition of myosin light chain kinase by p21-activated kinase.
p21-activated kinases (PAKs) are implicated in the cytoskeletal changes induced by the Rho family of guanosine triphosphatases. Cytoskeletal dynamics are primarily modulated by interactions of actin and myosin II that are regulated by myosin light chain kinase (MLCK)-mediated phosphorylation of the regulatory myosin light chain (MLC). p21-activated kinase 1 (PAK1) phosphorylates MLCK, resulting in decreased MLCK activity. MLCK activity and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID