Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region.

Tebar F, Confalonieri S, Carter RE, Di Fiore PP, Sorkin A

Eps15 is a member of an emerging family of proteins containing a novel protein/protein interaction domain, the EH domain, of as yet unknown function. Recent findings of Eps15 association with clathrin adaptor complex AP-2 and its localization in clathrin-coated pits have implicated Eps15 in the regulation of vesicle trafficking. Here we show that Eps15 exists in several multimeric states in ... [more]

J. Biol. Chem. Jun. 13, 1997; 272(24);15413-8 [Pubmed: 9182572]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
EPS15 EPS15	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Tebar F (1997)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

EPS15

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [IPI]polyubiquitin binding [ISO]protein binding [IPI]

Gene Ontology Cellular Component