PRMT2
Gene Ontology Biological Process
- developmental cell growth [ISS]
- histone arginine methylation [IBA]
- histone methylation [IDA, ISS]
- negative regulation of G1/S transition of mitotic cell cycle [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of apoptotic process [IGI]
- positive regulation of transcription, DNA-templated [IDA]
- protein methylation [TAS]
- regulation of androgen receptor signaling pathway [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
Gene Ontology Cellular Component
KANK2
Gene Ontology Biological Process
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of intracellular estrogen receptor signaling pathway [IDA]
- negative regulation of programmed cell death [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.815781244 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.815781244, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRMT2 KANK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9797 | BioGRID | 1191618 |
Curated By
- BioGRID