BAIT
RALA
RAL
v-ral simian leukemia viral oncogene homolog A (ras related)
GO Process (10)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- actin cytoskeleton reorganization [IDA]
- chemotaxis [TAS]
- cytokinesis [IDA]
- membrane organization [TAS]
- membrane raft localization [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of filopodium assembly [IDA]
- regulation of exocytosis [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RALBP1
ralA binding protein 1
GO Process (9)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- endocytosis [IMP]
- mitotic spindle organization [IDA]
- negative regulation of smooth muscle cell proliferation [IMP]
- positive regulation of Cdc42 GTPase activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- regulation of GTPase activity [ISO]
- small GTPase mediated signal transduction [IPI, ISO]
- transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.
Ral is a small GTPase involved in critical cellular signaling pathways. The two isoforms, RalA and RalB, are widely distributed in different tissues, with RalA being enriched in brain. The best characterized RalA signaling pathways involve RalBP1 and phospholipase D. To investigate RalA signaling in neuronal cells we searched for RalA-binding proteins in brain. We found at least eight proteins ... [more]
J. Biol. Chem. Aug. 10, 2001; 276(32);29792-7 [Pubmed: 11406615]
Throughput
- Low Throughput
Curated By
- BioGRID