BAIT
ICAM1
BB2, CD54, P3.58
intercellular adhesion molecule 1
GO Process (18)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [IMP]
- adhesion of symbiont to host [IDA]
- cell adhesion [IDA]
- cytokine-mediated signaling pathway [TAS]
- establishment of endothelial barrier [IGI]
- extracellular matrix organization [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte cell-cell adhesion [IMP]
- leukocyte migration [IEP]
- membrane to membrane docking [IEP]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cellular extravasation [IMP]
- receptor-mediated virion attachment to host cell [IDA]
- regulation of immune response [TAS]
- regulation of leukocyte mediated cytotoxicity [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AHR
bHLHe76
aryl hydrocarbon receptor
GO Process (15)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- blood vessel development [NAS]
- circadian regulation of gene expression [ISS]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of B cell proliferation [IDA]
- regulation of gene expression [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to toxic substance [IDA]
- response to xenobiotic stimulus [IDA]
- transcription from RNA polymerase II promoter [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- DNA binding [IDA, TAS]
- E-box binding [ISS]
- Hsp90 protein binding [IDA]
- enhancer binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein heterodimerization activity [TAS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, TAS]
- E-box binding [ISS]
- Hsp90 protein binding [IDA]
- enhancer binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein heterodimerization activity [TAS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.946346342 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.946346342, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID