KCND2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- dendrite [IDA]
- dendritic spine [IDA, ISO]
- integral component of plasma membrane [IDA]
- membrane [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear endoplasmic reticulum [IDA]
- plasma membrane [IDA]
- postsynaptic density [IDA]
- potassium channel complex [IDA]
- voltage-gated potassium channel complex [IDA]
KCNIP4
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.
Presenilin (PS) genes linked to early-onset familial Alzheimer's disease encode polytopic membrane proteins that are presumed to constitute the catalytic subunit of gamma-secretase, forming a high molecular weight complex with other proteins. During our attempts to identify binding partners of PS2, we cloned CALP (calsenilin-like protein)/KChIP4, a novel member of calsenilin/KChIP protein family that interacts with the C-terminal region of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID