ACVR1B
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- activin receptor signaling pathway [IDA, IMP]
- extrinsic apoptotic signaling pathway [IMP]
- negative regulation of cell growth [IDA]
- nodal signaling pathway [IGI]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of trophoblast cell migration [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
Gene Ontology Cellular Component
ACVR1
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- G1/S transition of mitotic cell cycle [IMP]
- activin receptor signaling pathway [IDA]
- atrial septum primum morphogenesis [IMP]
- cardiac muscle cell fate commitment [IMP]
- embryonic heart tube morphogenesis [IMP]
- endocardial cushion cell fate commitment [IMP]
- mitral valve morphogenesis [IMP]
- negative regulation of activin receptor signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of signal transduction [IMP]
- pathway-restricted SMAD protein phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of ossification [IMP]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA]
- peptide hormone binding [NAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA]
- peptide hormone binding [NAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors.
Truncated activin type II receptors have been reported to inhibit activin receptor signaling in Xenopus embryos, although the mechanism of action for this effect has not been fully understood. In the present study we demonstrate that in P19 embryonal carcinoma cells both the induction of the activin responsive 3TP-lux reporter construct and the inhibition of retinoic acid-induced neuronal differentiation by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACVR1 ACVR1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9189 | BioGRID | 1196621 | |
| ACVR1 ACVR1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9959 | BioGRID | 3150896 | |
| ACVR1 ACVR1B | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.0373 | BioGRID | 3585021 |
Curated By
- BioGRID