BAIT
FOXF1
ACDMPV, FKHL5, FREAC1
forkhead box F1
GO Process (22)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- blood vessel development [IMP]
- branching involved in open tracheal system development [IMP]
- cardiac left ventricle morphogenesis [IMP]
- digestive tract development [IMP]
- ductus arteriosus closure [IMP]
- embryonic digestive tract morphogenesis [IMP]
- embryonic ectodermal digestive tract morphogenesis [IMP]
- endocardial cushion development [IMP]
- heart development [IMP]
- in utero embryonic development [IMP]
- lung development [IMP]
- lung vasculature development [IMP]
- midgut development [IMP]
- morphogenesis of a branching structure [IMP]
- pancreas development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- renal system development [IMP]
- respiratory tube development [IMP]
- transcription from RNA polymerase II promoter [IBA]
- ureter development [IMP]
- venous blood vessel development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- sequence-specific DNA binding [ISS]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP2R5D
B56D
protein phosphatase 2, regulatory subunit B', delta
GO Process (23)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- carbohydrate metabolic process [TAS]
- dephosphorylation [TAS]
- energy reserve metabolic process [TAS]
- glucose metabolic process [TAS]
- glycolytic process [TAS]
- innate immune response [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of catalytic activity [TAS]
- small molecule metabolic process [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.864274987 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.864274987, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID