ARNTL
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA, ISS]
- circadian rhythm [TAS]
- negative regulation of TOR signaling [ISS]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- oxidative stress-induced premature senescence [ISS]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of circadian rhythm [ISS]
- positive regulation of skeletal muscle cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- regulation of cell cycle [ISS]
- regulation of cellular senescence [ISS]
- regulation of hair cycle [IMP]
- regulation of insulin secretion [ISS]
- regulation of neurogenesis [ISS]
- regulation of transcription, DNA-templated [ISS]
- regulation of type B pancreatic cell development [ISS]
- response to redox state [IDA]
- spermatogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- E-box binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- aryl hydrocarbon receptor binding [IPI]
- core promoter binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
- DNA binding [IDA, IGI]
- E-box binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- aryl hydrocarbon receptor binding [IPI]
- core promoter binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
NPAS2
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- central nervous system development [TAS]
- circadian regulation of gene expression [ISS]
- negative regulation of cell death [IMP]
- positive regulation of DNA repair [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of response to DNA damage stimulus [IMP]
- response to redox state [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.
Circadian clock genes are expressed in the suprachiasmatic nucleus and in peripheral tissues to regulate cyclically physiological processes. Synchronization of peripheral oscillators is thought to involve humoral signals, but the mechanisms by which these are mediated and integrated are poorly understood. We report a hormone-dependent interaction of the nuclear receptors, RAR alpha and RXR alpha, with CLOCK and MOP4. These ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARNTL NPAS2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9988 | BioGRID | 2232693 | |
| NPAS2 ARNTL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3169212 | |
| ARNTL NPAS2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 3137010 | |
| NPAS2 ARNTL | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| ARNTL NPAS2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2724027 | |
| NPAS2 ARNTL | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| ARNTL NPAS2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID