BAIT
AXIN1
Axin
axin 1
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, ISO]
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [ISO]
- adult walking behavior [ISO]
- axial mesoderm development [ISO]
- axial mesoderm formation [IBA, ISO]
- canonical Wnt signaling pathway [ISO, TAS]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [ISO]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IBA, ISO]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IBA, ISO]
- dorsal/ventral pattern formation [ISO]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IBA, ISO]
- erythrocyte homeostasis [ISO]
- forebrain anterior/posterior pattern specification [IBA]
- genetic imprinting [ISO]
- hemoglobin metabolic process [ISO]
- in utero embryonic development [ISO]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [ISO, TAS]
- negative regulation of canonical Wnt signaling pathway [IBA, ISO]
- negative regulation of fat cell differentiation [IBA, ISO]
- negative regulation of protein metabolic process [ISO]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- neurological system process [ISO]
- nucleocytoplasmic transport [ISO]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- post-anal tail morphogenesis [ISO]
- protein catabolic process [ISO]
- protein homooligomerization [IDA, ISO]
- protein polyubiquitination [ISO]
- regulation of catenin import into nucleus [IBA, ISO]
- regulation of protein phosphorylation [ISO]
- sensory perception of sound [ISO]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- beta-catenin destruction complex [IDA, ISO]
- cell cortex [IBA, ISO]
- cell periphery [ISO]
- cytoplasm [ISO]
- cytoplasmic membrane-bounded vesicle [IBA, ISO]
- cytoplasmic microtubule [IBA, ISO]
- cytoplasmic vesicle [IDA]
- lateral plasma membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
Rattus norvegicus
PREY
GSK3B
glycogen synthase kinase 3 beta
GO Process (35)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- ER overload response [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- axon guidance [TAS]
- canonical Wnt signaling pathway [IC, IDA]
- cellular response to interleukin-3 [ISS]
- circadian rhythm [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial to mesenchymal transition [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glycogen metabolic process [IDA]
- hippocampus development [IMP]
- innate immune response [TAS]
- intracellular signal transduction [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of protein binding [IDA]
- negative regulation of protein complex assembly [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein catabolic process [IC]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein export from nucleus [IDA]
- protein phosphorylation [IDA]
- regulation of microtubule-based process [IMP]
- superior temporal gyrus development [IMP]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
The N-terminal region of Dvl-1 (a mammalian Dishevelled homolog) shares 37% identity with the C-terminal region of Axin, and this related region is named the DIX domain. The functions of the DIX domains of Dvl-1 and Axin were investigated. By yeast two-hybrid screening, the DIX domain of Dvl-1 was found to interact with Dvl-3, a second mammalian Dishevelled relative. The ... [more]
Mol. Cell. Biol. Jun. 01, 1999; 19(6);4414-22 [Pubmed: 10330181]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXIN1 GSK3B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| GSK3B AXIN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID