BAIT
AXIN1
Axin
axin 1
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, ISO]
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [ISO]
- adult walking behavior [ISO]
- axial mesoderm development [ISO]
- axial mesoderm formation [IBA, ISO]
- canonical Wnt signaling pathway [ISO, TAS]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [ISO]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IBA, ISO]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IBA, ISO]
- dorsal/ventral pattern formation [ISO]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IBA, ISO]
- erythrocyte homeostasis [ISO]
- forebrain anterior/posterior pattern specification [IBA]
- genetic imprinting [ISO]
- hemoglobin metabolic process [ISO]
- in utero embryonic development [ISO]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [ISO, TAS]
- negative regulation of canonical Wnt signaling pathway [IBA, ISO]
- negative regulation of fat cell differentiation [IBA, ISO]
- negative regulation of protein metabolic process [ISO]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- neurological system process [ISO]
- nucleocytoplasmic transport [ISO]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- post-anal tail morphogenesis [ISO]
- protein catabolic process [ISO]
- protein homooligomerization [IDA, ISO]
- protein polyubiquitination [ISO]
- regulation of catenin import into nucleus [IBA, ISO]
- regulation of protein phosphorylation [ISO]
- sensory perception of sound [ISO]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- beta-catenin destruction complex [IDA, ISO]
- cell cortex [IBA, ISO]
- cell periphery [ISO]
- cytoplasm [ISO]
- cytoplasmic membrane-bounded vesicle [IBA, ISO]
- cytoplasmic microtubule [IBA, ISO]
- cytoplasmic vesicle [IDA]
- lateral plasma membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
Rattus norvegicus
PREY
CTNNB1
CTNNB, MRD19, armadillo, OK/SW-cl.35
catenin (cadherin-associated protein), beta 1, 88kDa
GO Process (48)
GO Function (20)
GO Component (23)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- adherens junction assembly [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISS]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [IMP]
- cell adhesion [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to growth factor stimulus [IMP]
- cellular response to indole-3-methanol [IDA]
- embryonic skeletal limb joint morphogenesis [ISS]
- endothelial tube morphogenesis [IMP]
- epithelial to mesenchymal transition [TAS]
- hair cell differentiation [TAS]
- innate immune response [TAS]
- muscle cell differentiation [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of mitotic cell cycle, embryonic [ISS]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- patterning of blood vessels [IC]
- positive regulation of DNA-templated transcription, initiation [IC]
- positive regulation of apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IGI]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [IMP]
- positive regulation of histone H3-K4 methylation [IC]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- protein localization to cell surface [IMP]
- regulation of angiogenesis [TAS]
- regulation of calcium ion import [IDA]
- regulation of cell fate specification [IBA]
- regulation of centriole-centriole cohesion [IDA]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of fibroblast proliferation [TAS]
- regulation of nephron tubule epithelial cell differentiation [ISS]
- regulation of protein localization to cell surface [IDA]
- regulation of smooth muscle cell proliferation [IMP]
- response to drug [IEP]
- response to estradiol [IDA]
- single organismal cell-cell adhesion [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [ISS]
Gene Ontology Molecular Function- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- adherens junction [IDA]
- beta-catenin destruction complex [IDA]
- beta-catenin-TCF7L2 complex [IDA]
- catenin complex [IDA]
- cell cortex [IDA]
- cell junction [IDA, TAS]
- cell periphery [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- lateral plasma membrane [IDA]
- membrane [ISS]
- nuclear euchromatin [IDA]
- nucleoplasm [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- protein-DNA complex [IDA]
- transcription factor complex [IDA]
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
The N-terminal region of Dvl-1 (a mammalian Dishevelled homolog) shares 37% identity with the C-terminal region of Axin, and this related region is named the DIX domain. The functions of the DIX domains of Dvl-1 and Axin were investigated. By yeast two-hybrid screening, the DIX domain of Dvl-1 was found to interact with Dvl-3, a second mammalian Dishevelled relative. The ... [more]
Mol. Cell. Biol. Jun. 01, 1999; 19(6);4414-22 [Pubmed: 10330181]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXIN1 CTNNB1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID