GSK3B
Gene Ontology Biological Process
- ER overload response [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- axon guidance [TAS]
- canonical Wnt signaling pathway [IC, IDA]
- cellular response to interleukin-3 [ISS]
- circadian rhythm [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial to mesenchymal transition [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glycogen metabolic process [IDA]
- hippocampus development [IMP]
- innate immune response [TAS]
- intracellular signal transduction [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of protein binding [IDA]
- negative regulation of protein complex assembly [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein catabolic process [IC]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein export from nucleus [IDA]
- protein phosphorylation [IDA]
- regulation of microtubule-based process [IMP]
- superior temporal gyrus development [IMP]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
AXIN1
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, ISO]
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [ISO]
- adult walking behavior [ISO]
- axial mesoderm development [ISO]
- axial mesoderm formation [IBA, ISO]
- canonical Wnt signaling pathway [ISO, TAS]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [ISO]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IBA, ISO]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IBA, ISO]
- dorsal/ventral pattern formation [ISO]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IBA, ISO]
- erythrocyte homeostasis [ISO]
- forebrain anterior/posterior pattern specification [IBA]
- genetic imprinting [ISO]
- hemoglobin metabolic process [ISO]
- in utero embryonic development [ISO]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [ISO, TAS]
- negative regulation of canonical Wnt signaling pathway [IBA, ISO]
- negative regulation of fat cell differentiation [IBA, ISO]
- negative regulation of protein metabolic process [ISO]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- neurological system process [ISO]
- nucleocytoplasmic transport [ISO]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- post-anal tail morphogenesis [ISO]
- protein catabolic process [ISO]
- protein homooligomerization [IDA, ISO]
- protein polyubiquitination [ISO]
- regulation of catenin import into nucleus [IBA, ISO]
- regulation of protein phosphorylation [ISO]
- sensory perception of sound [ISO]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- beta-catenin destruction complex [IDA, ISO]
- cell cortex [IBA, ISO]
- cell periphery [ISO]
- cytoplasm [ISO]
- cytoplasmic membrane-bounded vesicle [IBA, ISO]
- cytoplasmic microtubule [IBA, ISO]
- cytoplasmic vesicle [IDA]
- lateral plasma membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
The N-terminal region of Dvl-1 (a mammalian Dishevelled homolog) shares 37% identity with the C-terminal region of Axin, and this related region is named the DIX domain. The functions of the DIX domains of Dvl-1 and Axin were investigated. By yeast two-hybrid screening, the DIX domain of Dvl-1 was found to interact with Dvl-3, a second mammalian Dishevelled relative. The ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXIN1 GSK3B | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| AXIN1 GSK3B | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID