BAIT
ADCYAP1
PACAP
adenylate cyclase activating polypeptide 1 (pituitary)
GO Process (15)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- cAMP-mediated signaling [IMP]
- cell-cell signaling [TAS]
- female pregnancy [TAS]
- neuron projection development [IDA]
- neuropeptide signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of Rap GTPase activity [IDA]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IDA]
- regulation of protein localization [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CPAMD8
K-CAP, VIP
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide of the secretin-vasoactive intestinal peptide (VIP) family. To investigate whether PACAP alters chief cell function, we prepared isolated chief cells (> 90% pure) from guinea pig stomach. PACAP-38, PACAP-27, VIP, and secretin all caused a threefold increase in pepsinogen release. The dose-response curves of PACAP-38, PACAP-27, and VIP were biphasic, ... [more]
Am. J. Physiol. Dec. 01, 1992; 263(6);G901-7 [Pubmed: 1335692]
Throughput
- Low Throughput
Curated By
- BioGRID