BAIT
SYNJ2BP
ARIP2, OMP25
synaptojanin 2 binding protein
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
PREY
ACVR2B
ACTRIIB, ActR-IIB, HTX4
activin A receptor, type IIB
GO Process (15)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [IMP]
- artery development [ISS]
- blood vessel remodeling [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of osteoblast differentiation [IMP]
- regulation of transcription, DNA-templated [IDA]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway.
Using yeast two-hybrid screening, we have identified a mouse Postsynaptic density 95/Discs large/Zona occludens-1 (PDZ) protein that interacts with activin type II receptors (ActRIIs). We named the protein activin receptor-interacting protein 2 (ARIP2). ARIP2 was found to have one PDZ domain in the NH(2)-terminal region and interact specifically with ActRIIs among the receptors for the transforming growth factor beta family ... [more]
J. Biol. Chem. May. 24, 2002; 277(21);19008-18 [Pubmed: 11882656]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SYNJ2BP ACVR2B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID