IL6ST
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- interleukin-27-mediated signaling pathway [IMP]
- interleukin-6-mediated signaling pathway [IMP]
- leukemia inhibitory factor signaling pathway [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of interleukin-6-mediated signaling pathway [IDA]
- oncostatin-M-mediated signaling pathway [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of acute inflammatory response [IC]
- positive regulation of adaptive immune response [IC]
- positive regulation of cardiac muscle hypertrophy [TAS]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation vascular endothelial growth factor production [TAS]
- response to cytokine [IDA]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
Gene Ontology Cellular Component
PRKCD
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- RNA metabolic process [TAS]
- activation of phospholipase C activity [TAS]
- apoptotic process [IDA, TAS]
- blood coagulation [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular senescence [IMP]
- cytokine-mediated signaling pathway [TAS]
- defense response to bacterium [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to oxidative stress [TAS]
- mRNA metabolic process [TAS]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of actin filament polymerization [ISS]
- negative regulation of filopodium assembly [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- negative regulation of inflammatory response [IC]
- negative regulation of insulin receptor signaling pathway [ISS, TAS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of platelet aggregation [ISS]
- negative regulation of protein binding [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- neutrophil activation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of ceramide biosynthetic process [IMP]
- positive regulation of glucosylceramide catabolic process [IMP]
- positive regulation of phospholipid scramblase activity [IMP]
- positive regulation of protein dephosphorylation [IMP]
- positive regulation of response to DNA damage stimulus [IMP]
- positive regulation of sphingomyelin catabolic process [IMP]
- positive regulation of superoxide anion generation [IMP]
- protein phosphorylation [IDA]
- protein stabilization [NAS]
- regulation of receptor activity [TAS]
- signal transduction [TAS]
- termination of signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.
The transcriptional regulation of Stat proteins is controlled through their C-terminal domains, which harbor both a tyrosine phosphorylation site, required for dimerization and subsequent nuclear translocation, and a serine phosphorylation site, required for maximum transcriptional activity. Previously, we reported that protein kinase Cdelta (PKCdelta) phosphorylates and interacts with Stat3 in an interleukin (IL)-6-dependent manner. In this study, we further characterized ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID