IL6ST
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- interleukin-27-mediated signaling pathway [IMP]
- interleukin-6-mediated signaling pathway [IMP]
- leukemia inhibitory factor signaling pathway [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of interleukin-6-mediated signaling pathway [IDA]
- oncostatin-M-mediated signaling pathway [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of acute inflammatory response [IC]
- positive regulation of adaptive immune response [IC]
- positive regulation of cardiac muscle hypertrophy [TAS]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation vascular endothelial growth factor production [TAS]
- response to cytokine [IDA]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
Gene Ontology Cellular Component
STAT3
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISS, TAS]
- astrocyte differentiation [ISS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [ISS]
- eye photoreceptor cell differentiation [ISS]
- glucose homeostasis [ISS]
- growth hormone receptor signaling pathway [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [ISS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein import into nucleus [IDA]
- radial glial cell differentiation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- sexual reproduction [ISS]
- signal transduction [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.
The transcriptional regulation of Stat proteins is controlled through their C-terminal domains, which harbor both a tyrosine phosphorylation site, required for dimerization and subsequent nuclear translocation, and a serine phosphorylation site, required for maximum transcriptional activity. Previously, we reported that protein kinase Cdelta (PKCdelta) phosphorylates and interacts with Stat3 in an interleukin (IL)-6-dependent manner. In this study, we further characterized ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
STAT3 IL6ST | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID