CD81
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- phosphatidylinositol biosynthetic process [ISO]
- phosphatidylinositol metabolic process [ISO]
- positive regulation of 1-phosphatidylinositol 4-kinase activity [ISO]
- positive regulation of B cell proliferation [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of cell proliferation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein localization [ISO]
- regulation of cell motility [IGI]
- regulation of cell proliferation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IGSF8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins.
CD81 exerts a range of interesting effects on T cells including early thymocyte differentiation, LFA-1 activation, and provision of costimulation. To better understand the mechanisms by which CD81 influences T cell function we evaluated CD81 molecular complexes on T cells. The most prominent CD81-associated cell surface protein on thymocytes as well as a number of T cell and B cell ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD81 IGSF8 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.815 | BioGRID | 2663583 |
Curated By
- BioGRID