BAIT
NCOA3
ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, RP5-1049G16.3
nuclear receptor coactivator 3
GO Process (10)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- cellular response to hormone stimulus [IBA]
- histone acetylation [IDA]
- intracellular receptor signaling pathway [IBA]
- positive regulation of gene expression [IMP]
- positive regulation of keratinocyte differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [NAS]
- receptor transactivation [TAS]
- regulation of RNA biosynthetic process [IMP]
Gene Ontology Molecular Function- androgen receptor binding [NAS]
- histone acetyltransferase activity [IDA]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA]
- nuclear hormone receptor binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- thyroid hormone receptor binding [NAS]
- transcription coactivator activity [IDA, IMP, NAS]
- androgen receptor binding [NAS]
- histone acetyltransferase activity [IDA]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA]
- nuclear hormone receptor binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- thyroid hormone receptor binding [NAS]
- transcription coactivator activity [IDA, IMP, NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
NR5A2
B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2
nuclear receptor subfamily 5, group A, member 2
GO Process (9)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- embryo development [TAS]
- endocrine pancreas development [TAS]
- gene expression [TAS]
- homeostatic process [NAS]
- intracellular receptor signaling pathway [TAS]
- positive regulation of transcription, DNA-templated [IDA, TAS]
- positive regulation of viral genome replication [IDA]
- regulation of transcription, DNA-templated [IDA, TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- phospholipid binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- phospholipid binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner.
The orphan nuclear hormone receptor liver receptor homologous protein-1 (LRH-1; NR5A2, also known as FTF), an unusual receptor that binds DNA as a monomer, is an essential regulator of expression of a rate-limiting enzyme in bile acid formation, cholesterol 7-alpha-hydroxylase. In a classic negative feedback loop that is a crucial component of the complex regulation of cholesterol metabolism, cholesterol 7-alpha-hydroxylase ... [more]
J. Biol. Chem. Jan. 25, 2002; 277(4);2463-7 [Pubmed: 11668176]
Throughput
- Low Throughput
Additional Notes
- mammalian two-hybrid, SHP competes with SRC-3 for interaction with LRH-1 in vivo
Curated By
- BioGRID