CCR4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCL3
Gene Ontology Biological Process
- MAPK cascade [IEP, IMP]
- T cell chemotaxis [IDA]
- astrocyte cell migration [ISS]
- behavior [IDA]
- calcium ion transport [IDA]
- calcium-mediated signaling [IDA]
- cell activation [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemotaxis [IDA]
- cytoskeleton organization [IDA]
- eosinophil chemotaxis [IDA]
- eosinophil degranulation [IDA]
- exocytosis [IDA]
- granulocyte chemotaxis [IDA]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lymphocyte chemotaxis [IDA]
- macrophage chemotaxis [ISS]
- monocyte chemotaxis [IC, IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of bone mineralization [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of osteoclast differentiation [IDA]
- neutrophil chemotaxis [IDA]
- osteoblast differentiation [IEP]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of calcium ion import [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of inflammatory response [ISS]
- positive regulation of interleukin-1 beta secretion [ISS]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein kinase B signaling [IEP]
- positive regulation of tumor necrosis factor production [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of sensory perception of pain [IDA]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- response to cholesterol [IDA]
- response to toxic substance [IDA]
- signaling [IEP]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4.
We have cloned the murine homologue of human CC Chemokine Receptor-4 (CC CKR-4). In equilibrium competition binding assays performed in undifferentiated HL-60 cells transfected with human and murine CC CKR-4 cDNA, the IC50 values for the binding of [125I]macrophage inflammatory protein-1 alpha to human and murine CC CKR-4 were 14.5 +/- 9.0 nM and 10.1 +/- 3.0 nM, respectively, and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID