BAIT

CASP4

ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX

caspase 4, apoptosis-related cysteine peptidase

Alzheimer's Disease Project

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

apoptotic process [TAS]

execution phase of apoptosis [IBA]

regulation of inflammatory response [IBA]

Gene Ontology Molecular Function

cysteine-type endopeptidase activity [IBA]

Gene Ontology Cellular Component

AIM2 inflammasome complex [IBA]

IPAF inflammasome complex [IBA]

NLRP3 inflammasome complex [IBA]

cytoplasm [IBA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

IL18

IGIF, IL-18, IL-1g, IL1F4

interleukin 18

GO Process (24)

GO Function (2)

GO Component (4)

Gene Ontology Biological Process

MAPK cascade [IMP]

T-helper 1 type immune response [IDA]

angiogenesis [IDA]

cell-cell signaling [TAS]

cellular response to organic cyclic compound [IDA]

chemokine biosynthetic process [TAS]

granulocyte macrophage colony-stimulating factor biosynthetic process [TAS]

immune response [TAS]

inflammatory response [IDA]

interferon-gamma biosynthetic process [TAS]

interleukin-13 biosynthetic process [TAS]

interleukin-2 biosynthetic process [TAS]

lipopolysaccharide-mediated signaling pathway [IDA]

positive regulation of NK T cell proliferation [IDA]

positive regulation of activated T cell proliferation [IDA]

positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]

positive regulation of inflammatory response [IC]

positive regulation of interferon-gamma production [IDA]

positive regulation of interleukin-17 production [IDA]

positive regulation of natural killer cell proliferation [IDA]

positive regulation of tissue remodeling [IC]

regulation of cell adhesion [IDA]

type 2 immune response [TAS]

Gene Ontology Molecular Function

cytokine activity [TAS]
protein binding [IPI]

Gene Ontology Cellular Component

extracellular region [TAS]

extracellular space [IBA]

extracellular vesicular exosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Biochemical Activity (Proteolytic Processing)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.

Kumar S, Hanning CR, Brigham-Burke MR, Rieman DJ, Lehr R, Khandekar S, Kirkpatrick RB, Scott GF, Lee JC, Lynch FJ, Gao W, Gambotto A, Lotze MT

We have recently reported the identification of four novel members of the interleukin-1 (IL-1) family which we designated as IL-1 homologue 1-4 (IL-1H1-4). These proteins exhibit significant sequence homology to other members of the IL-1 family. Of these homologues, only IL-1H4 (renamed IL-1F7b) was predicted to contain a propeptide domain and a caspase cleavage site. We now report that caspase-1 ... [more]

Cytokine Apr. 21, 2002; 18(2);61-71 [Pubmed: 12096920]

Throughput

Low Throughput

Curated By

BioGRID