BAIT
GZMB
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GO Process (6)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SRGN
PPG, PRG, PRG1
serglycin
GO Process (11)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- T cell secretory granule organization [ISS]
- blood coagulation [TAS]
- granzyme-mediated apoptotic signaling pathway [IDA]
- maintenance of granzyme B location in T cell secretory granule [ISS]
- maintenance of protease location in mast cell secretory granule [ISS]
- mast cell secretory granule organization [ISS]
- negative regulation of bone mineralization [IDA]
- negative regulation of cytokine secretion [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- protein processing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
We have recently shown that the physiological mediator of granule-mediated apoptosis is a macromolecular complex of granzymes and perforin complexed with the chondroitin-sulfate proteoglycan, serglycin (Metkar, S. S., Wang, B., Aguilar-Santelises, M., Raja, S. M., Uhlin-Hansen, L., Podack, E., Trapani, J. A., and Froelich, C. J. (2002) Immunity 16, 417-428). We now report our biophysical studies establishing the nature of ... [more]
J. Biol. Chem. Dec. 20, 2002; 277(51);49523-30 [Pubmed: 12388539]
Throughput
- Low Throughput
Curated By
- BioGRID