GZMB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SRGN
Gene Ontology Biological Process
- T cell secretory granule organization [ISS]
- blood coagulation [TAS]
- granzyme-mediated apoptotic signaling pathway [IDA]
- maintenance of granzyme B location in T cell secretory granule [ISS]
- maintenance of protease location in mast cell secretory granule [ISS]
- mast cell secretory granule organization [ISS]
- negative regulation of bone mineralization [IDA]
- negative regulation of cytokine secretion [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- protein processing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
We have recently shown that the physiological mediator of granule-mediated apoptosis is a macromolecular complex of granzymes and perforin complexed with the chondroitin-sulfate proteoglycan, serglycin (Metkar, S. S., Wang, B., Aguilar-Santelises, M., Raja, S. M., Uhlin-Hansen, L., Podack, E., Trapani, J. A., and Froelich, C. J. (2002) Immunity 16, 417-428). We now report our biophysical studies establishing the nature of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID