CIDEA
Gene Ontology Biological Process
- cell death [ISS]
- lipid metabolic process [ISS]
- lipid storage [ISS]
- negative regulation of cytokine secretion [IMP]
- negative regulation of execution phase of apoptosis [ISS]
- negative regulation of lipid catabolic process [IMP, ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISS]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of sequestering of triglyceride [ISS]
- regulation of apoptotic DNA fragmentation [ISS]
- regulation of apoptotic process [IBA]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CIDEB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis.
Cell death-inducing DFF45-like effector (CIDE)-B is a member of the novel family of apoptosis-inducing factors that share homology with the N-terminal region of DFF, the DNA fragmentation factor. The molecular mechanism of CIDE-B-induced apoptosis is unclear. We have shown here that CIDE-B protein is localized in mitochondria and forms homodimers and heterodimers with other family members. Serial deletion analyses suggest ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID