STX4
Gene Ontology Biological Process
- blood coagulation [TAS]
- intracellular protein transport [IBA]
- long-term synaptic potentiation [IDA]
- membrane organization [TAS]
- organelle fusion [IDA]
- platelet activation [TAS]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of chemotaxis [IMP]
- positive regulation of eosinophil degranulation [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of immunoglobulin secretion [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IDA, IMP]
- positive regulation of protein localization to cell surface [IMP]
- positive regulation of protein localization to plasma membrane [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of exocytosis [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- response to hydroperoxide [IDA]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- basolateral plasma membrane [IDA]
- cell surface [IDA]
- cytosol [TAS]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IBA]
- intracellular [IDA]
- lamellipodium [IDA]
- membrane [IDA]
- plasma membrane [IDA, TAS]
- somatodendritic compartment [IDA]
- specific granule [IDA]
- synapse [IDA]
- synaptic vesicle [IBA]
- vacuole [TAS]
SNAP25
Gene Ontology Biological Process
- energy reserve metabolic process [TAS]
- glutamate secretion [TAS]
- neurotransmitter secretion [TAS]
- neurotransmitter uptake [NAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [NAS, TAS]
- synaptic vesicle docking [NAS]
- synaptic vesicle exocytosis [TAS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- synaptic vesicle priming [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.
The specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP-25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are ubiquitously expressed proteins and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX4 SNAP25 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| STX4 SNAP25 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| STX4 SNAP25 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID