BAIT
UNC13B
MUNC13, UNC13, Unc13h2
unc-13 homolog B (C. elegans)
GO Process (7)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SNAP25
RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2
synaptosomal-associated protein, 25kDa
GO Process (11)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- energy reserve metabolic process [TAS]
- glutamate secretion [TAS]
- neurotransmitter secretion [TAS]
- neurotransmitter uptake [NAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [NAS, TAS]
- synaptic vesicle docking [NAS]
- synaptic vesicle exocytosis [TAS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- synaptic vesicle priming [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.
unc-13 mutants in Caenorhabditis elegans are characterized by a severe deficit in neurotransmitter release. Their phenotype is similar to that of the C. elegans unc-18 mutation, which is thought to affect synaptic vesicle docking to the active zone. This suggests a crucial role for the unc-13 gene product in the mediation or regulation of synaptic vesicle exocytosis. Munc13-1 is one ... [more]
J. Biol. Chem. Jan. 24, 1997; 272(4);2520-6 [Pubmed: 8999968]
Throughput
- Low Throughput
Curated By
- BioGRID