BAIT
VAMP2
SYB2, VAMP-2
vesicle-associated membrane protein 2 (synaptobrevin 2)
GO Process (29)
GO Function (9)
GO Component (25)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISS]
- calcium ion-dependent exocytosis [ISS]
- cellular protein metabolic process [TAS]
- cellular response to insulin stimulus [ISS]
- energy reserve metabolic process [TAS]
- eosinophil degranulation [IMP]
- exocytosis [IBA, TAS]
- glutamate secretion [TAS]
- long-term synaptic potentiation [ISS]
- membrane fusion [ISS]
- membrane organization [TAS]
- mucus secretion [IMP]
- natural killer cell degranulation [IMP]
- neurotransmitter secretion [TAS]
- neutrophil degranulation [IMP]
- positive regulation of intracellular protein transport [ISS]
- post-Golgi vesicle-mediated transport [TAS]
- protein complex assembly [ISS]
- protein transport [ISS]
- regulation of exocytosis [ISS]
- regulation of histamine secretion by mast cell [IMP]
- regulation of insulin secretion [TAS]
- regulation of vesicle-mediated transport [ISS]
- response to glucose [ISS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [ISS, TAS]
- vesicle fusion [IBA]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA, TAS]
- clathrin-coated vesicle [IDA]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- clathrin-sculpted glutamate transport vesicle membrane [TAS]
- clathrin-sculpted monoamine transport vesicle membrane [TAS]
- cytoplasmic vesicle [ISS]
- endocytic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [ISS]
- membrane [IDA]
- neuron projection [ISS]
- neuron projection terminus [ISS]
- perinuclear region of cytoplasm [ISS]
- plasma membrane [ISS, TAS]
- secretory granule [ISS]
- secretory granule membrane [IDA, TAS]
- synapse [ISS]
- synaptic vesicle [IBA, ISS, TAS]
- synaptic vesicle membrane [ISS]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [ISS]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [ISS]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISS]
- trans-Golgi network [ISS]
- zymogen granule membrane [ISS]
Homo sapiens
PREY
VAMP8
EDB, VAMP-8
vesicle-associated membrane protein 8
GO Process (13)
GO Function (3)
GO Component (15)
Gene Ontology Biological Process
- autophagic vacuole fusion [IMP]
- endocytosis [IBA]
- eosinophil degranulation [IMP]
- exocytosis [IBA]
- membrane organization [TAS]
- mucus secretion [IMP]
- negative regulation of secretion by cell [IDA]
- neutrophil degranulation [IMP]
- positive regulation of histamine secretion by mast cell [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of protein localization to plasma membrane [IDA]
- vesicle fusion [IBA]
- viral entry into host cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- azurophil granule membrane [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- membrane [IDA]
- mucin granule [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- recycling endosome [IDA]
- secretory granule membrane [IDA, TAS]
- vesicle [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.
Secretion of platelet granules is necessary for normal hemostasis. Platelet secretion requires soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complex formation between different members of the syntaxin, SNAP-25, and vesicle-associated membrane protein (VAMP) gene families. Using microcapillary reverse-phase high-performance liquid chromatography-nano-electrospray tandem mass spectrometry, we identified VAMP-3 and VAMP-8 as VAMP isoforms coimmunoprecipitated from platelets with syntaxin 4. Immunoblotting ... [more]
Blood Aug. 01, 2002; 100(3);1081-3 [Pubmed: 12130530]
Throughput
- Low Throughput
Curated By
- BioGRID