CD3E
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- T cell activation [NAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [NAS]
- intracellular signal transduction [TAS]
- positive regulation of T cell proliferation [IMP]
- protein complex assembly [NAS]
- regulation of apoptotic process [NAS]
- regulation of immune response [TAS]
- signal complex assembly [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CD3G
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell activation [NAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [IMP]
- establishment or maintenance of cell polarity [IMP]
- innate immune response [TAS]
- protein complex assembly [NAS]
- protein transport [IMP]
- regulation of immune response [TAS]
- regulation of lymphocyte apoptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex.
Assembly of the six-chain T cell antigen receptor-CD3 complex takes place by pairwise interactions. Thus, CD3-epsilon interacts with either CD3-gamma or CD3-delta, and these dimers then associate with the TCR heterodimer (alpha.beta or gamma.delta) and the CD3-zeta homodimer to constitute a full complex. We have now mapped the site in CD3-epsilon responsible for the interaction with CD3-gamma and CD3-delta by ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID