CBL
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of receptor-mediated endocytosis [TAS]
- protein ubiquitination [TAS]
- regulation of transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTK2B
Gene Ontology Biological Process
- activation of Janus kinase activity [IMP]
- angiogenesis [IBA]
- apoptotic process [TAS]
- bone resorption [ISS]
- cell surface receptor signaling pathway [IMP]
- cellular defense response [ISS]
- cellular response to retinoic acid [IMP]
- chemokine-mediated signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- integrin-mediated signaling pathway [IMP]
- ionotropic glutamate receptor signaling pathway [ISS]
- long-term synaptic potentiation [ISS]
- marginal zone B cell differentiation [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of bone mineralization [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of myeloid cell differentiation [IMP]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of potassium ion transport [IDA]
- peptidyl-tyrosine autophosphorylation [IBA, ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of B cell chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- positive regulation of protein kinase activity [IMP]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- protein autophosphorylation [TAS]
- protein complex assembly [TAS]
- protein phosphorylation [TAS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of actin cytoskeleton reorganization [ISS]
- regulation of cell adhesion [IMP]
- regulation of cell shape [IMP]
- regulation of establishment of cell polarity [ISS]
- regulation of inositol trisphosphate biosynthetic process [ISS]
- regulation of macrophage chemotaxis [ISS]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of release of sequestered calcium ion into cytosol [ISS]
- response to stress [TAS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- tumor necrosis factor-mediated signaling pathway [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- apical dendrite [ISS]
- cell body [ISS]
- cytoplasm [IDA]
- cytosol [TAS]
- dendrite [ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA]
- growth cone [ISS]
- lamellipodium [IDA]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility.
The signaling events downstream of integrins that regulate cell attachment and motility are only partially understood. Using osteoclasts and transfected 293 cells, we find that a molecular complex comprising Src, Pyk2, and Cbl functions to regulate cell adhesion and motility. The activation of integrin alpha(v)beta(3) induces the [Ca(2+)](i)-dependent phosphorylation of Pyk2 Y402, its association with Src SH2, Src activation, and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTK2B CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CBL PTK2B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PTK2B CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID